研究方向
本实验室主要关注于细胞应激和稳态调控相关研究，目前主要集中于三大研究方向：1）细胞对线粒体损伤的应激机制；2）细胞对营养物质匮乏的应激机制；3）DNA 6mA甲基化的调控机制及其生理病理意义。实验室综合利用秀丽线虫、哺乳动物细胞、小鼠、病人样本等多模式从事相关研究。研究成果将会为癌症、代谢疾病和衰老相关疾病的治疗提供新的理论基础。
代表性科研论文
1. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife(2019) e41792.
2. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology (2018) DOI: 10.1038/s41556-018-0238-5.
3. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature 557(2018) 585-589.
4. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin extends C. elegans lifespan through lysosomal pathway. eLife 6 (2017) e31268.
5. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 11 (2016) 1182-1196. (cover story)
6. Berendzen K, Durieux J, Shao L, Tian Y, Kim H, Wolff S, Liu Y and Dillin A*. Neuroendocrine coordination of mitochondrial stress signaling and proteostasis. Cell 166 (2016) 1553-1563.
7. Liu Y, Samuel BS, Breen PC and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) doi:10.1038/nature13204.
8. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q*. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44 (2011) 502-508.
9. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q*. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941 (2009) 750-753.
