题 目:Viral decision making: Some recent findings and ongoing work
报告人: Ido Golding, Ph.D.
Professor of Biochemistry and Molecular Biology, Baylor College of Medicine
Professor of Physics and Microbiology (affiliate), University of Illinois at Urbana Champaign
时 间: 4月11日（周一）上午9:00-10:00
地 点: ZOOM线上报告
Meeting ID: 910 9636 7823
主持人: 齐志 研究员
Viral dormancy, in which the infected cell is not killed but rather becomes the long-term residence of the parasite, is a hallmark of viruses across kingdoms, from bacteriophages to HIV. When and how viruses decide to opt for this lifestyle remains mysterious. Phage lambda, which serves as a paradigm for viral dormancy, is reported to count the number of coinfecting viruses and then use this value to assess the abundance of potential hosts and decide whether to become dormant. We use a single-cell measurement of viruses and their expressed genes, together with mathematical modeling, to illuminate how lambda performs this task. I will discuss some of our recent findings and ongoing work.
Professor Ido Golding received his Ph.D. in physics from Tel Aviv University (Israel) in 2001. Originally trained as a condensed matter theorist, he later spent five years learning the experimental arsenal of modern molecular biology as a Lewis Thomas Fellow at Princeton University. Prof. Golding joined the faculty of the Department of Physics at the University of Illinois at Urbana-Champaign in 2007. In 2019, he returned to the Department from Baylor College of Medicine, where he had been a Professor of Biochemistry and Molecular Biology. At Illinois, Golding is also an affiliate Professor of Microbiology and a member of the Center for the Physics of Living Cells.