报告人: 刘嘉 博士
时 间：2015年12月24日(星期四) 上午 10:00
Currently, there is intense interest in the development of materials and electronic devices that can extend and/or provide new capabilities for probing neural circuitry and providing long-term minimally invasive brain-electronics interfaces. Direct electrical recording and stimulation using micro-fabricated silicon and metal microwire probes have been extensively used over the past several decades for both basic neuroscience and neural therapeutic applications. These existing devices have limitations in terms of close integration and chronic deterioration of the probe implant-tissue interfaces, which have been attributed to factors such as size and mechanical mismatch between implants and brain tissue. Recent studies of smaller and more flexible probes suggest that addressing these factors may overcome existing limitations, yet those flexible nanoelectronics are still difficult to be implemented into brain tissue when the mechanical properties are the same as that of tissue. Here, we overcome this challenge through the design, fabrication and demonstration of a syringe-injectable electronics as a general approach to precisely deliver three-dimensional (3D) macroporous nanoelectronic brain probe that combines ultra-flexibility and subcellular feature sizes into rodent brain. These macroporous probes, which mimick the key features of tissue scaffolds for tissue engineering, promote seamless integration with brain tissue and introduce minimal mechanical perturbation. These ultraflexible macroporous probes were used to record multiplexed local field potentials (LFP) and single-unit action potentials from the somatosensory cortex and hippocampus. Significantly, histology studies show that the mesh electronics exhibit unprecedented ‘neurophilicity’ as evidenced by the close proximity of neurons to and interpenetration neurofilaments with themacroporous electronics probe structure. These studies suggest that our syringe-injectable method and ultraflexible 3D macroporous electronic probes can provide new opportunities for chronic neural activity mapping and implants for next generation brain-machine interfaces.
Jia Liu completed his B.S. in Chemistry from Department of Chemistry at Fudan University in 2009 and received his Ph.D. degree in chemistry from Department of Chemistry and Chemical Biology at Harvard University in 2014. His Ph.D. research with Professor Charles M. Lieber included the fundamental studies of high performance nanomaterials as biosensors and applications of novel nanoelectronics in three-dimensional electronics, regenerative medicine and neuroscience. He is now working with Prof. Zhenan Bao as a postdoctoral fellow in the Department of Chemical Engineering at Stanford University for developing soft electronics and its applications in wearable electronics and biomedical devices.