Nanocombinatorics Through Scanning-Probed Based Chemistry and Biology
报 告 人：Prof. Chad A. Mirkin
Department of Chemistry and International Institute for Nanotechnology
Northwestern University, USA
时 间：2015年11月7日(星期六) 下午5:00
Microfabrication and printing techniques have revolutionized the world but still too distant from the benchtop prototype devices. Recently, massively parallel scanning-probe based methods have been used to address these challenges and mark a step towards the realization of a “desktop fab.” Such a tool should enable simple, flexible, high-throughput, and low-cost nano- and microscale patterning; this tool will allow scientists to rapidly synthesize and study systems pertaining to nanoparticle catalysis, single particle electronic devices, and biochemical processes at the cell surface. Cantilever-free scanning probe based methods are promising in that they are intrinsically low cost, high resolution, and massively parallelizable. Initially, we developed polymer pen lithography (PPL), which uses arrays of elastomeric tips that rest on a rigid backing layer to transfer chemically reactive ‘inks’ (e.g. alkanethiols, proteins, polymers) in a direct-write manner onto a variety of surfaces. Recent advances in PPL have created the ability to create combinatorial libraries with varying feature size and ink composition. The science and development of PPL has enabled researchers to systematically investigate phenomena in chemistry, biology, and materials science. Specifically, the ability to pattern nanoreactors on a substrate through the technique called scanning probe block copolymer lithography (SPBCL) has allowed us to investigate nanoparticle catalysis. SPBCL patterns individual nanoreactors of metal-coordinated block copolymers onto a substrate which is then used to direct the synthesis of a single nanoparticle per reactor. Changing the composition and concentration of the metal precursors on the pen array allows for fine control of the final composition and size (2 – 50 nm) of the resulting nanoparticle. Combining the ability to make high density, large area combinatorial patterns with the ever expanding library of SPBCL nanoparticles that can be synthesized on the surface, we can then probe their material properties in a systematic and controlled way and ultimately understand their catalytic activity.
Dr. Chad A. Mirkin is the Director of the International Institute for Nanotechnology and the George B. Rathmann Prof. of Chemistry, Prof. of Chemical and Biological Engineering, Prof. of Biomedical Engineering, Prof. of Materials Science & Engineering, and Prof. of Medicine at Northwestern University. He is a chemist and a world renowned nanoscience expert, who is known for his discovery and development of spherical nucleic acids (SNAs) and SNA-based biodetection and therapeutic schemes, the invention of Dip-Pen Nanolithography (DPN) and related cantilever-free nanopatterning methodologies, On-Wire Lithography (OWL), Co-axial Lithography (COAL), and contributions to supramolecular chemistry and nanoparticle synthesis. He is the author of over 620 manuscripts and over 960 patent applications worldwide (261 issued), and the founder of multiple companies, including Nanosphere, Inc., AuraSense, LLC, and Exicure, Inc., which are commercializing nanotechnology applications in the life science industry.
Dr. Mirkin has been recognized for his accomplishments with over 100 national and international awards. He is a Member of the President’s Council of Advisors on Science & Technology (Obama Administration), and one of only 19 scientists, engineers or medical doctors to be elected to all three US National Academies (Inst. of Medicine, Natl. Academy of Sci., and Natl. Academy of Engin.). He is also a Fellow of the American Academy of Arts and Sciences, the American Association for the Advancement of Science, and the Materials Research Society. Dr. Mirkin has served on the Editorial Advisory Boards of over 20 scholarly journals, and at present, he is an Associate Editor of JACS. He is the founding editor of the journal Small, one of the premier international nanotechnology journals, and he has co-edited three bestselling books.