报告人: Yuanyuan Zhang, MD, PhD
Institution: Wake Forest School of Medicine
Department: Wake Forest Institute for Regenerative Medicine Wake Forest University, NC, US
时间: 2018年4月19日(星期四) 16:40 ~ 17:30
Dr. Yuanyuan Zhang is a Director of Tissue Therapy and Associate Professor in the Wake Forest Institute for Regeneration Medicine (WFIRM) at Wake Forest University, Winston-Salem, North Carolina in USA. He received his M.D. from Nanchang Medical University in China and then got clinic training in New Zealand. He earned his PhD degree in University of Lausanne in Switzerland. After postdoc training, he became a faculty member at Wake Forest Institute for Regenerative Medicine, a premier environment for research in cell therapy and tissue regeneration. Dr. Zhang has conducted research in stem cell, cell therapy, tissue engineering, biomaterials, and regenerative medicine in kidney and urinary tract system for more than 20 years.
Dr. Yuanyuan Zhang was the first to demonstrate that stem cells exist in urine and that those cells (urine derived stem cells, USC), with self-renewal and multi-potent capacity, have a number of potential applications in cell-based therapy. Importantly, USC could be used as a noninvasive diagnostic tool in urinary tract tumors or other diseases. Dr. Zhang is also an expert in 3D organoids, decellularized extracellular matrix biological scaffolds, and alginate microspheres to deliver growth factors in treatment of various diseases in genitourinary tract system. He has a productive record of 164 original peer-reviewed research, review and chapter publications. Furthermore, he has received two NIH-funded grants as a PI, obtained 10 patents for his work and applied for 2 more. He serves as a guest editor or editorial board member for 23 medicine or biomedicine journals and a peer reviewer for 35 peer-reviewed journals in stem cells, tissue engineering, biomaterials surgery, urology, andrology, and the related fields.
Current in vitro biological tools to study various kidney diseases include monolayer cell cultures and small animal models. Monolayer cell cultures cannot completely represent the human kidney because they miss renal tissue-specific function and 3D structure. Rodent models are insufficient to properly replicate the fashions of damages observed in humans. Biofabricated 3D culture of kidney organoids would be a highly applicable approach of in vitro evaluation of renal stem cell function, dysfunction and nephrotoxicity. We are the first to demonstrate human urine-derived stem cells (USC) originated from glomerular parietal stem cells. These cells possess self-renewal and multi-potent capacity and can be obtained from noninvasive method. The goal of this study is to investigate 3D USC-induced proximal tubule tissue model to study renal tissue damage and disease progression of kidney problems.