报告人: Prof. Shay Soker
Institute for Regenerative Medicine
Center of Public Health Genomics
Center on Diabetes, Obesity, and Metabolism Cancer Biology
Wake Forest University, NC, USA
时间: 2018年4月19日(星期四) 14:40 ~ 15:30
Shay Soker is a Professor of Regenerative Medicine, Cancer Biology, Physiology & Pharmacology and Biomedical Engineering at the Wake Forest School of Medicine. Dr. Soker received his PhD degree from the Technion-Israel Institute for Technology and completed a postdoctoral training at the Children’s Hospital Boston and Harvard Medical School. Later, he became an Assistant Professor in Surgery at the Harvard Medical School. In 2004 Dr Shay Soker moved to the Wake Forest University School of Medicine as an Associate Professor in Regenerative Medicine and was promoted to the rank of Professor in 2010.
Among Dr. Soker’s research contributions are the integration of molecular and cellular biology principles in regenerative medicine applications. His research interests focus on vascular biology, identification of stem and progenitors cells that are needed for tissue damage repair and regeneration, and the biochemical nature of biomaterials that can be used for tissue engineering. Specific example is the use of tissue-derived extracellular matrices as scaffolds for whole organ bioengineering. Some of Dr. Soker’s projects are now being discussed with industry collaborators in order to create new regenerative medicine product. Dr. Soker has published more than 150 research manuscripts in scientific journals. Dr. Soker obtained funding for his research from different sources including NIH, DoD, NCI, the state of North Carolina, private foundations and industry.
Dr. Soker’s presentation will focus of bioengineering of functional organs. He has published a seminal manuscript describing, for the first time, the making of a functional human liver using liver extracellular matrix seeded with liver progenitor and endothelial cells. The engineered livers were kept in a perfusion bioreactor to mature and create clusters of hepatocytes, biliary structures and a vasculature. He is now using a similar approach to bioengineer kidney, pancreas and intestine. In parallel, he created small tissue constructs (organoids) as models for organ function, development and disease and for drug testing.