YIHAN LIN

Research Area:

Our lab focuses on dissecting the regulatory mechanisms underlying cell state heterogeneity and cell fate control in disease-relevant cell types, including stem cells, immune cells, and cancer cells. By combining new quantitative single-cell tools with systems and synthetic biology approaches, we are investigating key determining factors for cell state heterogeneity and cell fate control. By doing so, we aim to achieve a deeper understanding of key biological processes including development, immunity and disease at the single-cell level. Ultimately, these efforts will allow us to design new therapeutics using drug combinations or synthetic gene circuits. 

Main Publications:

 •At PKU:

1. Yan Wu, Jiaqi Wu, Minghua Deng, Yihan Lin*. Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs. Nature Communications 2021, 12(1), 1-13 (*corresponding author).

2. Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*. Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells. Molecular Systems Biology 2020, 16, e9335 (*corresponding author).

3. Jianhan Zhang#, Xu Han#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology 2018, 16(12): e3000095 (*corresponding author).

4. Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B. Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems2018, 7(4): 453-462.

5. Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, …, Michael B. Elowitz*, Molecular time sharing through dynamic pulsing in single cells, Cell Systems 2018, 6(2): 216-229.

6. Liang Ma, Zeyue Gao, Jiegen Wu, Bijunyao Zhong, Yuchen Xie, Wen Huang, Yihan Lin*. Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics. Molecular Cell 2021, 81, 1-16  (*corresponding author).

•Prior to PKU:

1. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai & Michael B. Elowitz*. Combinatorial gene regulation by modulation of relative pulse timing, Nature 2015, 527(7576):54-58. 

2. Joseph H. Levine#, Yihan Lin#, & Michael B. Elowitz*. Functional roles of pulsing in genetic circuits. Science, 342(6163): 1193-1200, 2013 (# co-first author).

3. Yihan Lin and Michael B. Elowitz*, Central dogma goes digital, Molecular Cell, 61: 791-792, 2016.

4. Yihan Lin, Ying Li, Sean Crosson, Aaron R. Dinner* & Norbert F. Scherer*, Phase resetting reveals network dynamics underlying a bacterial cell cycle, PLOS Computational Biology, 8(11): e1002778, 2012. 

5. Yihan Lin, Sean Crosson* & Norbert F. Scherer*, Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion, Molecular Systems Biology, 6: 445, 2010.