题 目: New bioluminescence-based technologies
报告人: Dr. Karen Sarkisyan
MRC London Institute of Medical Sciences
时 间: 11月2日（周一）17:00-18:00
地 点: Online (Zoom会议)
会议 ID：640 8468 0249
主持人: Lucas Carey
I will talk about new bioluminescence-based technologies and our recent work on engineering organisms with self-sustained luminescence, in particular, autoluminescent plants. We have recently discovered the genes and molecules responsible for bioluminescence of tropical fungi. The fungal bioluminescence system converts caffeic acid, a metabolite present in all plants, into luciferin. We introduced the fungal molecular pathway into the plants, generating glow-in-the-dark transgenic tobacco plants with self-sustained luminescence visible to the naked eye. We hope that this technology could underpin development of a suite of imaging tools for plants.
Karen Sarkisyan completed his PhD on fluorescent protein development with Konstantin Lukyanov and Alexander Mishin at the Institute of Bioorganic Chemistry in Moscow and then worked on protein evolution with Fyodor Kondrashov at the Centre for Genomic Regulation in Barcelona and Institute of Science and Technology in Vienna. In 2018, Karen moved to the MRC London Institute of Medical Sciences to start his lab.
Karen′s lab work focuses on several research directions, both basic and applied, from studying the structure-function relationship in proteins to engineering bacterial strains that can perform directed evolution without human involvement. They approach these and other problems from the perspective of synthetic biology, investing time into automation of molecular biology routines and creating new molecular technologies for light-based computation and cell communication.