题 目: Using single cell tools to understand how cellular communities are organized
报告人: Dr. Adam Rosenthal
Senior Principal Investigator，Project leader (Human Microbiome Initiative)，DuPont, Wilmington Delaware,
时 间: 11月9日（周一）9:00-10:00
地 点: Online (Zoom会议)
会议 ID：627 9242 4126
主持人: Lucas Carey
Microbial communities are made up of interacting individuals that have distinct ecological niches. As far back as early microscopy, specialization has been observed not only in multi-species microbial communities, but also in the structure of genetically clonal microbial isolates. However, due to experimental limitations the physiological function of each cell-type and the coordinated interactions between different bacterial cell-types within these complex structures has remained largely unknown. In recent years, interest in understanding the organization of microbial communities, including clonal populations has resurfaced. In this seminar, I will present recent works in which single-cell tools were used to discover the physiological role of different bacterial players in a clonal population of Bacillus subtilis. Interestingly, we find that even in a clonal population of bacteria different cell-types not only co-exist, but coordinate their metabolism for the greater good of the community. Understanding the way in which this coordination is regulated, and the properties that are conserved across different biological systems, may explain important features of infectious disease including the expression of virulence genes and antibiotic persistence. In addition, these findings may offer insights into how cellular differentiation and homeostasis are regulated in multi-cellular organisms..
Dr. Adam Rosenthal was raised in a Kibbutz in southern Israel, where an early exposure to farming and nature shaped his curiosity of biological systems. He got his bachelor and master degree in biology. His PhD studies, in Jay Gralla’s lab (UCLA), explored the mechanisms by which bacteria adapt to stresses in the mammalian digestive tract. After graduating, motivated to understand microbial cell-cell interactions in complex settings, he studied the mutually beneficial symbiosis between termites and their hindgut bacteria, and the inner-workings of microbial communities in Jared Leadbetter’s and Michael Elowitz's labs in Caltech. He have since been applying the tools and approaches he learned in his PhD and Postdocs to industrial setting, first as a group leader at Calico (Google's startup focused on aging) and currently as a Team Leader at DuPont.