HEPING CHENG

Publication

1.Cheng, H., Lederer, W.J., Cannell., M.B., 1993, Calcium sparks: Theelementary events underlying excitation-contraction coupling in heart muscle.Science 262, 740-744 

2.Cheng, H., Fill, M., Valdivia,H.H., Lederer, W.J., 1995,Models of calcium release channel adaptation, Science 267,2009-2010  

3.Cannell, M.B., Cheng, H., Lederer, W.J., 1995, The control of calciumrelease in heart muscle. Science268, 1045-1050

4.Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A., Knot, H.,Lederer, W.J., 1995, Relaxation of arterial smooth muscle by calcium sparks.Science 270, 633-637 

5.Klein, M.G., Cheng, H.*, Santana, L.F., Lederer, W.J., Schneider, M.F.,1996, Discrete sarcomeric calcium release events activated by dual mechanisms inskeletal muscle. Nature 379, 455-458 (* the corresponding author)

6.Gomez, A.M., Valdivia, H.H., Cheng, H., Santana, L.F., Lederer, W.J.,1997, Defective excitation-contraction coupling in experimental cardiachypertrophy and heart failure. Science 276, 800-806 

7.Wang, S.Q., Song, L.-S., Lakatta, E.G., Cheng, H., 2001, Ca²⁺signalling between single L-type Ca²⁺ channels and ryanodinereceptors in heart cells. Nature 410, 592-596 

8.Pan, Z., Yang, D., Nagaraj, R.Y., Nosek, T.A., Nishi, M. Takeshima, H.,Cheng, H., Ma, J., 2002, Dysfunction of store-operated Ca²⁺channel in muscle cells lacking mg29 gene. Nature CellBiol. 4, 379-383 

9.Wang, S.Q., Stern, M.D., Ríos, E., Cheng, H., 2004,The quantal nature ofca²⁺ sparks and in situ operation of the ryanodine receptorarray in cardiac cells. Proc. Natl. Acad. Sci. USA 101,3979-3984 

10.Wang, S.Q., Wei, C.L., Gao, G. L., Brochet, D., Shen, J.X., Song, L.S., Wang,W., Yang, D.M., Cheng, H., 2004, Imaging microdomain Ca²⁺ inmuscle cells. Circ. Res. 94, 1011-1022 (invited review) 

11.Wang, W., Zhu, W., Wang, S. Q., Yang, D. M., Crow, M. T., Xiao, R. P., Cheng,H., 2004, Sustained b₁-adrenergic stimulation modulates cardiaccontractility by Ca²⁺/calmodulin kinase signaling pathway.Circ. Res. 95,798-806. 

12.Xu, X., Yang, D., Ding, J., Wang, W., Chu, P. H., Dalton, N. D., Wang, H. Y.,Bermingham, J. R., Jr., Ye, Z., Liu, F., Rosenfeld, F. G., Manley, J. L., RossJ., Jr., Chen, J., Xiao, R.-P., Cheng, H., Fu, X. D., 2005,ASF/SF2-regulated postnatal reprogramming of CaMKIId alternative splicingmodulates excitation-contraction coupling in cardiac muscle. Cell,120, 59-72

13.Brochet, D. X. P., Yang, D., Di Maio, A., Lederer, W. J., Franzini-Armstrong,C., Cheng, H., 2005, Calcium blinks: Rapid nanoscopic store calciumsignaling. Proc. Natl. Acad. Sci. USA, 102,3099-3104 

14.Ouyan, K., Wu, C. H., Cheng, H., 2005, Ca²⁺-inducedCa²⁺ release in sensory neurons: Low-gain amplification confersintrinsic stability. J. Biol. Chem. 280, 15898-15902 

15.Ouyang, K., Zheng, H., Qin, X., Zhang, C., Yang, D., Wang, X., Wu, C., Zhou, Z.,and Cheng, H., 2005, Ca²⁺ sparks and secretion in dorsal rootganglion neurons. Proc. Natl. Acad. Sci. USA.102:12259-12264 

16.Song, L-S, Sobie, EA, McCulle, S, Lederer, WJ, Balke, CW, Cheng, H.,2006, Orphaned ryanodine receptors in the failing heart. Proc. Natl. Acad.Sci. USA. 103: 4305-4310 

17.Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M,Yin J, Wang W, Mattson MP, Kao JP.Y, Lakatta EG, Sheu S-S, Ouyang K, Chen J,Dirksen RT,Cheng H., 2008,Superoxide Flashes in Single Mitochondria. Cell, 2008; 134:279-290. 

18.Cheng, H., Lederere, W.J., 2008,Calcium sparks,Physiol. Reviews. 88,1491-1545 

19.Wei, C.L., Wang, X.H, Chen, M., Ouyang, K.F., Song, L.S., Cheng, H., 2009, Calcium flickers steercell migration. Nature 457, 901-905. 

20. Zhou, P., Zhao, Y.T., Guo, Y.B., Xu,S.M., Bai, S.H., Lakatta, E.G., Cheng, H., Hao, X.M., Wang,S.Q., 2009, β-adrenergicsignaling accelerates and synchronizes cardiac ryanodine receptor response to asingle L-type Ca²⁺ channel. Proc. Natl.Acad. Sci. U S A, 106, 18028-33  

21.Wang, G.,  Zhu, X., Xie, W., Han, P., Li,K., Sun, Z., Wang, Y., Chen, C., Song,R., Cao, C., Zhang, J., Wu, C., Liu, J.,Cheng,H.,2010, Rad as a novel regulator of excitation- contraction coupling andβ-adrenergic signaling in heart. CircRes.106， 317-327

22.Wei, C.L., Wang, X.H., Chen, M., Ouyang, K.F., Zheng, M., Cheng, H., 2010, Flickeringcalcium signals turning of migrating cells. CanJ Physiol Pharm.  88,105-110  

23.Peng, W., Zhang, Y., Zheng, M., Cheng,H., Zhu, W., Cao, C.M., Xiao, R.P. 2010, Cardioprotectionby CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 andsubsequent expression of inducible heat shock protein 70. CircRes.106, 102-110  

24.Wang,X,, Xie, W., Zhang, Y., Lin, P., Han, L., Han, P., Wang, Y., Chen, Z., Ji, G.,Zheng, M., Weisleder, N., Xiao, R.P., Takeshima, H, Ma, J, Cheng, H., 2010, Cardioprotection ofischemia/reperfusion injury by cholesterol-dependent MG53-mediated membranerepair. CircRes.107,76-83.  

25.Wei, S., Guo, A., Chen, B., Kutschke, W., Xie, Y.P., Zimmerman, K., Weiss, R.M.,Anderson, M.E., Cheng, H., Song, L.S. 2010,T-tubule remodeling during transition from hypertrophy to heart failure.  CircRes.107，520-531  

26.Xie, W., Brochet, D.X., Wei, S., Wang, X., Cheng, H 2010, Decipheringryanodine receptor array operation in cardiac myocytes. JGen Physiol.136, 129-133 

27.  Wei,C., Wang, X.,  Zheng, M,Cheng, H.2011, Calciumgradients underlying cell migration. Curr Opin Cell Biol. 2011 Dec 21. [Epub ahead ofprint] 

28.Brochet,DX., Xie, W., Yang, D., Cheng, H.,Lederer W.J., 2011,  Quarky calcium release in theheart, Circ Res , 108,210-218. 

29.Fang, H., Chen, M., Ding, Y., Shang, W., Xu, J., Zhang, X., Zhang, W., Li, K.,Xiao, Y., Gao, F., Shang, S., Li, J., Tian, X., Wang, S., Zhou, J., Weisleder,N., Ma,J., Ouyang, K., Chen, J., Wang, X., Zheng, M., Wang, W., Zhang, X., Cheng, H., 2011, Imaging superoxideflash and metabolism-coupled mitochondrial permeability transition in livinganimals, Cell Res, 21,1295-1304.  

30.Han, P., Cai, W., Wang, Y., Lam, C., Arvanitis, D., Singh, V.P., Chen, S.,Zhang, H., Zhang, R., Cheng, H.,Kranias, E.G., 2011, Catecholaminergic-induced arrhythmias in failingcardiomyocytes associated with human HRCS96A variant overexpression, Am J Physiol-Heart C,301, H1588-1595.  

31.Huang, Z., Zhang, W., Fang, H., Zheng, M., Wang, X., Xu, J., Cheng, H., Gong, G., Wang, W., Dirksen,R.T., Sheu, S., 2011, Response to "A critical evaluation of cpYFP as a probe forsuperoxide", Free Radical Bio Med, 51, 1937-1940. 

32.Lin, N., Badie, N., Yu, L., Abraham, D.,Cheng, H., Bursac, N., Rockman, H.A., Wolf, M.J., 2011, A method to measuremyocardial calcium handling in adult Drosophila, Circ Res, 108, 1306-1315. 

33.Ma, Q., Fang, H., Shang, W., Liu, L., Xu, Z., Ye, T., Wang, X., Zheng, M., Chen,Q., Cheng, H.,2011, Superoxideflashes: early mitochondrial signals for oxidative stress-induced apoptosis, JBiol Chem, 286, 27573-27581. 

34.Zhang, X., Zhang, R., Raab, S., Zheng, W., Wang, J., Liu, N., Zhu, T., Xue, L.,Song, Z., Mao, J., Li, K., Zhang, H., Zhang, Y., Han, C., Ding, Y., Wang, H.,Hou, N., Liu, Y., Shang, S., Li, C., Sebokova, E., Cheng, H., Huang, P., 2011, Rhesusmacaques develop metabolic syndrome with reversible vascular dysfunctionresponsive to pioglitazone, Circulation, 124, 77-86. 

35.Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., Smith, C.D.,Xie, C., Chen, W., Zhang, J., Tian, X., Jones, P., Zhong, X., Guo, A., Chen, H.,Zhang, L., Zhu, W., Yang, D., Li, X., Chen, J., Gillis, A.M., Duff, H.J., Cheng, H., Feldman, A.M., Song, L.,Fill, M., Back, T.G., Chen, S.R., 2011, Carvedilol and its new analogs suppressarrhythmogenic store overload-induced Ca²⁺ release, NatMed, 17, 1003-1009. 

36.Wang, X. H.,Jian, C. S.,,Zhang, X.,  Huang, Z. L., Xu, J. J,. Hou, T. T., Shang, W.,Ding, Y. Zhang, W. R. Ouyang, M. Wang, Y. F., Yang, Z.,  Zheng M., Cheng,H., 2012, Superoxide flashes: Elementalevents of mitochondrial ROS signaling in the heart. JMol Cell Cardiol 52,940-948.37.Li,K.,

37.Zhang, W. R., Fang, H. Q., Xie, W. J., Liu, J. Zheng, M. Wang, X. H., Wang, W.,Tan, W. C., Cheng, H. 2012, Superoxide Flashes RevealNovel Properties of Mitochondrial Reactive Oxygen Species Excitability inCardiomyocytes. Biophysical J,102,1011-1021.