研究方向

创新和发展单分子荧光成像、单细胞测序、生物信息分析等多学科交叉融合方法，研究临床复杂疾病致病机制，探索新的治疗方法。近年来研究重点关注：1）人体正常组织中存在的体细胞突变与肿瘤发生；2）循环肿瘤细胞与癌症多器官转移；3）单细胞精度解析儿童免疫疾病致病机制；4）抗生素杀菌原理和细菌耐药的分子机制。

代表性科研论文

1. Li F#, Xing X#, Jin Q#, ……, Yu C*, Chen L*,Bai F*, Gao D*, Sex differences orchestrated by androgens at single-cell resolution,Nature629 (2024), 193-200

2. Chen L#, Zhang C#, Xue R#, ……, Wu L*, Rozen SG*,Bai F*, Wang H*, Deep whole genome analysis of 494 hepatocellular carcinomas,Nature624 (2024), 586-593

3. Li R#, Di L#, Li J#, ……, Lin D*, Huang Y*, Wang J*,Bai F*, Wu C*, A body map of somatic mutagenesis in morphologically normal human tissues,Nature597 (2021), 398-403

4. Wang J#, Xu Y#, Chen Z#, ……,Bai F*, Xia H*, Wen Z*, Zhang Y*, Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia,Cell183 (2020), 1867-1883

5. Li R#, Du Y#, Chen Z#, ……, Xu T*,Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium,Science370 (2020), 82-89

6. Zhang J#, Wang X#, Xing X#, …….,Bai F*, Wang F*, Single-cell landscape of immunological responses in patients with COVID-19,Nature Immunology21 (2020), 1107-1118

7. Huang B#, Chen Z#, Geng L#, ......, Gong S*,Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways,Cell179 (2019), 1160-1176

8. Xue R#, Chen L#, Zhang C#, ……, Nakagawa H*, Zeng M*,Bai F*, Zhang N*, Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes,Cancer Cell35 (2019), 932-947

9. Pu Y#, Li Y#, Jin X#, ……, Lo CJ,Bai F*, ATP-dependent dynamic protein aggregation regulates bacterial dormancy depth critical for antibiotic tolerance,Molecular Cell73 (2019), 1-14

10. Du Y#, Li R#, Chen Z#, Wang X, Xu T*,Bai F*, Mutagenic factors and complex clonal relationship of multifocal urothelial cell carcinoma,European Urology71 (2017), 841–843

11. Pu Y#, Zhao Z#, Li Y#, ……, Xie XS*,Bai F*, Enhanced efflux activity facilitates drug tolerance in dormant bacterial cells,Molecular Cell62 (2016), 284-294

12. Ni X#, Zhuo M#, Su Z#, ……,Bai F*, Xie X*, Wang J*, Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients,PNAS110 (2013), 21083-21088

13. Bai F#, Branch R#, Nicolau D#,……, Berry R*, Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch,Science327 (2010), 685-689