研究方向
放射化学生物学（Radiochemical Biology）
PET影像开辟了在分子层面上进行疾病诊断的新思路，它是精准医疗的排头兵。 近来，PET分子影像已成为了我国各大医院的常规检查项目，市场份额在2015年超过了100亿元。与X射线、CT及MRI等传统临床影像不同， PET影像的诊断效果依赖于放射性标记的分子探针。但是，由于放射化学的特殊性以及多学科融合的复杂性，我国在PET分子探针上的基础研究还相对落后，与国际先进水平差距巨大。即使是国内顶尖的医疗机构，也不得不从国外引进PET探针，辅助国内的临床研究。回国之后，我们计划在北大化院、北大-清华生命联合中心以及周边医学院所的支持下，搭建起我国第一个立足基础研究的PET分子影像平台，填补国内空白，切实推动我国精准医疗事业的发展。
主要的研究方向如下：
1. PET分子影像引导的活体蛋白激活及药物释放；
2. 外源放疗及内源核素衰变激活的活体蛋白激活及药物释放；
3. 含硼PET分子影像探针及硼中子捕获治疗药物的研究与临床应用;
4. 新型医用核素的加速器生产研究与临床应用。
代表性论文
1. Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han,Yaxin Shi,Zhibo Liu* Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo.ACS Appl. Mater. Interfaces.,2018,10 (49), 42165-42174
2. Yaxin Shi, Jiyuan Li, Zizhu Zhang, Dongban Duan, Zhengchu Zhang, Hui Liu, Tong Liu,Zhibo Liu*,Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy.ACS Appl. Mater. Interfaces.,2018,10 (50), 43387-43395
3. Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo,Zhibo Liu*, Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy.Mol Pharm.2018,15(10): 4426-4433.
4. Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang,Zhibo Liu*.Activating TiO2 Nanoparticle: Gallium-68 Serves As A High-Yielded Photon Emitter for Cerenkov Induced Photodynamic Therapy.ACS Appl. Mater. Interfaces.2018, 10 (6), 5278–5286
5. Hui Liu, Yuxiang Han, Jiyuan Li, Ming Qin, Qunfeng Fu, Chunhong Wang, Zhibo Liu*. A18F-labeled Alanine Derivative Serve as An ASCT2 Marker for Cancer Imaging.Mol Pharm.,2018,15 (3), 947-954
6. Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* (2015) A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc. 10: 1423–1432. (co-corresponding author).
7. Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* (2015) Boramino Acid as A Marker for Amino Acid Transporter. Science Advances 1: e1500694. (co-corresponding author, highlighted on C&EN News)
8. Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin (2014) An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed. 53: 11876–11880. (Cover feature, highlighted on C&EN News)
