研究方向

主要研究细胞分泌发生机理，细胞分泌和内吞的动力学，细胞离子通道、受体和动作电位，以及细胞分泌对神经、内分泌、心血管系统功能的贡献。我们使用膜片钳、细胞膜电容、电化学微碳纤电极、细胞内[Ca²⁺]i荧光测量、共聚焦荧光FM成像、光裂解细胞内钙离子络合物等先进生物物理技术，在单个细胞，新鲜组织薄片、或活体动物上进行电生理、电化学实时记录。擅长于改进已有的微电子、光学、机械仪器技术和分析理论，设计新的方法（装置和理论），通过与国内外生物医学专家开展优势互补的互利合作，来发现重要生物医学问题的答案。

代表性科研论文

1. Liu T, Sun L, Xiong YF, Shang SJ, Guo N, Teng SS, Wang YS, Liu B, Wang CH, Wang L, Zheng LH, Zhang CX, Han WP, Zhou Z, Calcium triggers exocytosis from two types of organelles in a single astrocyte. JOURNAL OF NEUROSCIENCE, in press, 2011.

2. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Zhang B, Xiong W, Chen XW, Zheng LH, Wang LY, Marc Landry, Hokfelt T, Xu ZQD and Zhou Z*, Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(4):1401-1406, 2006.

3. Chen XK, Wang LC, Zhou Y, Zheng LH and Zhou Z*, "Kiss-and-Run" glutamate secretion in culture and freshly isolatedrat hippocampal astrocytes, JOURNAL OF NEUROSCIENCE, 25(40):9236 –9243, 2005.

4. Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z*, Endogenous activation of GPCRs modulates quantal size in chromaffin cells: roles of Gbg and PKC, NATURE NEUROSCIENCE, 8(9):1160 – 1168, 2005.

5. Zhang C, Zhou Z*, Ca²⁺-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.NATURE NEUROSCIENCE, 5(5):425-30, 2002.