研究方向

来鲁华实验室主要利用物理化学、结构化学、计算和生物化学方法研究蛋白质及其参与的生命过程。试图揭示蛋白质序列、结构和功能的关系，探讨生物分子作用机理，开展蛋白质结构和功能设计，进行基于结构和基于系统的药物设计方法与应用研究。为了开展有针对性的生物分子设计，我们发展新的计算设计方法与程序，模拟生物分子机制及系统规律；同时注重计算与实验的密切结合，利用实验手段定量研究生物分子作用机制并进行蛋白质、药物和生物系统设计，试图提示生物系统运行的分子机制。

代表性科研论文

1. Zhou H, Zhong S, Song Z, Zuo L, Qi Z*, Qu LJ*,Lai L* (2019), Mechanism of DNA-induced phase separation for transcriptional repressor vrn1.Angew. Chem. Int. Ed.58:4858-4862.

2. Wang Q, Liberti MV, Liu P, Deng X, Liu Y, Locasale JW*,Lai L* (2017), Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.Cell Chem. Biol.24:55-65.

3. Meng H, Liu Y*,Lai L* (2015), Diverse Ways of Perturbing the Human Arachidonic Acid Metabolic Network To Control Inflammation.Acc.Chem. Res. 48:2242-2250.

4. Pei J, Yin N, Ma X,Lai L* (2014), Systems Biology Brings New Dimensions for Structure-Based Drug Design.J. Am. Chem. Soc.136:11556-11565.

5. Zhou L, Bosscher M, Zhang C, Ozcubukcu S, Zhang L, Zhang W, Li C, Liu J, Jensen MP,Lai L*, He C* (2014), A protein engineered to bind uranyl selectively and with femtomolar affinity.Nature Chem. 6:236-241.

6. Zhang C, Shen Q, Tang B,Lai L* (2013), Computational Design of Helical Peptides Targeting TNF.Angew. Chem. Int. Ed.52:11059-11062.

7. Bi S, Yu D, Si G, Luo C, Li T, Ouyang Q, Jakovljevic V, Sourjik V, Tu Y*,Lai L* (2013), Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity.Proc. Natl. Acad. Sci. USA. 110:16814-16819.

8. Yang K, Bai H, Ouyang Q,Lai L* (2008), Tang C, Finding multiple target optimal intervention in disease-related molecular network.Mol. Syst. Biol. 4:228.