宋晨

Email:c.song@pku.edu.cn

所在院系:前沿交叉学科研究院

主页:http://cqb.pku.edu.cn/songgroup/ 或 http://www.songgroup.org/

宋晨

  • Emailc.song(AT)pku.edu.cn

  • 联系电话010-62759559

  • 所在院系前沿交叉学科研究院

  • 实验室主页http://cqb.pku.edu.cn/songgroup/ 或 http://www.songgroup.org/

  • 办公室地址北京市海淀区颐和园路5号北京大学吕志和楼234室

详细描述


研究方向

宋晨研究组从事计算生物物理化学研究:运用多尺度计算模拟,研究离子通道等膜蛋白的微观功能机理,定量理解跨膜信号转导和物质转运过程;利用深度学习等方法,对膜蛋白的性质、结构和功能进行预测;探索膜蛋白的设计与改造等。


代表性科研论文

1. Kang, K.; Wang, L.;Song, C.* ProtRAP: Predicting Lipid Accessibility Together with Solvent Accessibility of Proteins in One Run.J. Chem. Inf. Model. 2023, 63, 1058-1065.

2. Wang, L.; Zhang, J.; Wang, D.;Song, C.* Membrane Contact Probability: An Essential and Predictive Character for the Structural and Functional Studies of Membrane Proteins.PLoS Comput. Biol. 2022, 18, e1009972.

3. Wang, Y.; Guo, Y.; Li, G.; Liu, C.; Wang, L.; Zhang, A.; Yan, Z.*;Song, C.* The Push-to-Open Mechanism of the Tethered Mechanosensitive Ion Channel NompC. eLife 2021, 10, e58388.

4. Zhang, A.; Yu, H.; Liu, C.;Song, C.* The Ca2+ Permeation Mechanism of the Ryanodine Receptor Revealed by a Multi-Site Ion Model.Nat. Commun. 2020, 11, 922.

5. Zhang, M.; Wang, D.; Kang, Y.; Wu, J.-X.; Yao, F.; Pan, C.; Yan, Z.*;Song, C.*; Chen, L.* Structure of the Mechanosensitive OSCA Channels.Nat. Struct. Mol. Biol. 2018, 25, 850–858.

6. Köpfer, D. A.;Song, C.*; Gruene, T.; Sheldrick, G. M.; Zachariae, U.*; de Groot, B. L.* Ion Permeation in K+ Channels Occurs by Direct Coulomb Knock-On.Science 2014, 346, 352–355.